МАКДОНАЛЬД Линн (US),МЕРФИ Эндрю Дж. (US),ГУРЕР Каган (US),МАКВИРТЕР Джон (US),ВОРОНИНА Вера (US),ХАРРИС Фейт (US),СТИВЕНС Шон (US)
申请号：
RU2014121323/10
公开号：
RU2014121323A
申请日:
2012.10.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The non-human animals kept on the endogenous locus of the major histocompatibility complex I (MHC I) a nucleotide sequence encoding a chimeric human / non-human polypeptide MHC I, and the human part of the chimeric polypeptide contains an extracellular domain of the polypeptide of human MHC I, not iprichem non-human animal expresses chimeric human / non-human polypeptide MHC I.2. Non-human animal according to Claim. 1, wherein the animal is a rodent, wherein the rodent comprises at the endogenous locus of major histocompatibility complex I (MHC I) a nucleotide sequence encoding a chimeric human / related to rodent polypeptide MHC I, the human part of the chimeric polypeptide comprises the extracellular domain of the polypeptide of human MHC I, iprichem rodent express chimeric human / rodent belonging to the MHC polypeptide I.3. The rodent of claim. 2, wherein the rodent does not express the extracellular domain of the polypeptide endogenous MHC I from endogenous rodent I MHC locus gryzuna.4. The rodent of claim. 2, in which the nucleotide sequence is operably linked with the endogenous regulatory elements gryzuna.5. The rodent of claim. 2, wherein the rodent is a mysh.6. The mouse of claim. 5 in which the endogenous locus is a locus of H-2K myshi.7. Rodent of claim. 2, in which the human part of the chimeric polypeptide contains a leader sequence cheloveka.8. Rodent of claim. 2, in which the human part of the chimeric polypeptide contains α1, α2 and α3 domains of the polypeptide MHC I cheloveka.9. The rodent of claim. 2, in which the part related to the rodent x
