PURPOSE: A food composition containing crude drug extract of Eleutherococcus senticosus and mistletoe is provided to suppress inflammation and to enhance antioxidation and liver function. CONSTITUTION: A food composition for preventing hangover contains crude drug extract of 15-30 weight parts of mistletoe, 20-40 weight parts of Eleutherococcus senticosus, 20-40 weight parts of Lycii Fructus, and Puerariae Radix as an active ingredient. The food composition additionally contains one or more selected from the group consisting of Glycyrrhizae radix, jujube, Zingiberis Rhizoma crudus, and Longanae Arillus.본 발명은 가시오가피, 겨우살이, 구기자 및 갈근를 포함하는 생약 원료의 추출물을 유효성분으로 포함하는 숙취 예방 및 해소용 식품 조성물에 대한 것이다.