The invention relates to systems and methods for collecting the content of IV lines that otherwise would be spilt in a hospital environment. In one general aspect the system includes an intravenous tubing system to prevent spillage of fluids. The IV tubing system includes intravenous tubing and a purge bag. The intravenous tubing includes a first end configured to attach to a fluid container and a second end having a connector. The purge bag includes at least one port, such as a needle-free valved port, configured to receive fluids from the intravenous tubing. The purge bag optionally contains a second port is configured to let air into or out of the purge bag with a closing means that may be a needle-free valved port. The purge bag can be packaged separately from the IV tubing set and the package can be opened at the time of use.