The present invention concerns a conjugate comprising (i) a cell binding agent which binds to the human mucin-1 (MUC1) glycoprotein, linked to (ii) at least one cytotoxic agent, for use to treat cancer, wherein said conjugate is administered at a dose of at least 120 mg/m2.本發明係關於一種綴合物,其包含:(i)與人黏蛋白-1(MUC1)醣蛋白結合之細胞結合劑,連接至(ii)至少一種細胞毒性劑,用於治療癌症,其中該綴合物之投藥劑量為至少120mg/m2。