INDUSTRY ACADEMIC COOPERATION FOUNDATION; HALLYM UNIVERSITY
发明人:
JUN, JONG GABKR,전종갑,YUN, SO RAKR,윤소라
申请号：
KR1020140024922
公开号：
KR1020150103446A
申请日:
2014.03.03
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a first and novel synthetic method of a moracin Y which is contained in mulberry leaves in an infinitesimal amount and exhibits an anticancer activity. The present invention includes a development of a novel synthetic method for efficiently synthesizing the moracin Y through three reaction stages which are a regioselective iodination, a sonogashira coupling, and a desilylation, starting from a 2,4-dihydroxybenzaldehyde which is a cheap compound.COPYRIGHT KIPO 2015본 발명은 뽕나무의 잎에 극소량 존재하며 항암 활성을 나타내는 모라신 Y의 신규한 최초 전합성 방법에 관한 것으로서, 값싼 디하이드록시벤즈알데히드 (2,4-dihydroxybenzaldehyde) 화합물로부터 위치선택적 요오드화반응 (regioselective iodination), 소노가시라 커플링 반응 (Sonogashira coupling), 디실릴화 반응 (desilylation) 등의 총 3단계 반응으로 효율적으로 모라신 Y를 합성하는 신규한 합성방법의 개발을 포함하는 것을 특징으로 한다.
