WU, GANG,WANG, YING,HUANG, YANTING,CARPENTER, JOSEPH E.
申请号：
ARP180103176
公开号：
AR113819A1
申请日:
2018.10.31
申请国别(地区):
AR
年份:
2020
代理人:
摘要：
Formula compound (1),Or stereoisomer, Dow, or acceptable salts or solutions of drugs, all of which are defined according to this definition. These compounds modularize the activity of the farnesoid X (FXR) receiver.Like dying, for example Including these compounds and pharmaceutical ingredients for the treatment of diseases, disorders or diseases related to the deregulation of FXR, such as pathological fibrosis, rejection of transplantation, cancer, osteoporosis and inflammation, the use of pharmaceutical compounds and synthesis. 1. Claim 1: a compound characterized by formula (1),O stereoisomer, a tautometer, a salt, or a solution acceptable to a medicament； where X1 and x830808n are C or n respectively； x2 and X3 are cr83099 respectively； and；N. No. 8310,O o s； ring e is carbohydrate or non carbohydrate with 4 to 6 members, in which carbohydrates and non carbohydrates are replaced at a rate of 0 to 3 cm3, respectively；*Denotes a carbon spiral atom, i.e. cr.8311 or N； m and N are integers 0, 1 or 2 each； F is an integer 0, 1, 2 or 3； Z is an arilo of 6 to 10 members, a pagan of 5 to 10 members, which contains 1 to 3 heteromorphic atoms selected from n, or s is a carbide with 3 to 10 members, O isomerization of 4 to 10 members, including 1 to 3 isomerization atoms independent of N or Y and s, in which arilo, isomerization, goiter and isomerization isomerization atoms independently replace 0 to 5 r831222；This is a covalent link, O, s, nr18310a,-S（o）8322-，e. C831833183323, the lessor, c831833183318323 isotar, c83283318324alquenileno, c832833183245-6 members of the tar, arilo or ISO tar, containing one to four heteroatoms separated from n, O and s, whether or not separated from n, N and S； 1. Heterosexual and heterosexual were replaced by 0-3 R1；This is a covalent link, O, s, Nr. 18311,e. For non tar, tar and non tar were replaced independently in 0-3 r8383090；Rx is l ° c-rz； L3 is a covalent link, c833218331832323lessor, - C (o) NR ° 1 ′ ch8322-o-och8322；c. C832183318
