An apparatus and method for selectively heating a biological target within a treatment region of a subject is disclosed. The method includes administering to the subject a dielectric heating modulator that becomes associated with the biological target. The method also includes positioning the treatment region between first and second electrodes connected to a generator, and activating the generator to apply an alternating electric field between the first and second electrodes and across the treatment region to thereby heat the treatment region. The dielectric heating modulator causes the biological target to heat at a faster rate than non-targets within the treatment region, which preferably results in the killing of the biological target.
