fusion protein, engineered cell to express fusion protein, vector, and method for treating a cancer patient

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

CARL H. JUNE,YANGBING ZHAO

申请号：

BR112014002006

公开号：

BR112014002006A2

申请日:

2012.07.27

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

The present invention relates generally to a fusion protein that when displayed on a cell can convert a negative signal into a positive signal in the cell. The fusion protein is a chimeric protein in that the protein comprises at least two domains, wherein the first domain is a polypeptide that is associated with a negative signal and the second domain is a polypeptide that is associated with a positive signal. Thus, the invention encompasses switch receptors that are able to switch negative signals to positive signals for enhancement of an immune response.

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中国工程科技知识中心

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http://www.ckcest.cn/home/