A conformable body interface includes a body scaffold comprising a three-dimensional lattice which can be removably placed over a three-dimensional soft-tissue surface, such as a knee, elbow, spine, ankle, wrist, hip, or neck. One or more sensors are located at one or more locations on the body scaffold, and the one or more locations are selected to position the sensor near a target region on the body surface when the body scaffold is placed over the three-dimensional body surface. Typically, the sensors are positioned near a body joint to detect motion of the body joint.
