MATEO DE ACOSTA DEL RIO, CRISTINA,VAZQUEZ LOPEZ, ANA MARIA,LOPEZ REQUENA, ALEJANDRO,FERNANDEZ MARRERO, YUNIEL,SOTO LOPEZ, YOSDEL,BRITO NAVARRO, VICTOR
申请号：
CA2758994
公开号：
CA2758994C
申请日:
2010.05.03
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to the field of biotechnology and particularlyto novel products for use in humanhealth. The present invention provides novel monoclonal antibodies thatspecifically and with high affinity recognize sulphatidesand sulphated proteoglycans. The anti-sulphatide and anti-sulphatedproteoglycan antibodies described in the present specificationconstitute important diagnostic and therapeutic agents for acting onpathological processes associated with the appearance ofatherosclerotic plaques. According thereto, the invention providespharmaceutical compositions that comprise the monoclonalantibodies of the invention or fragments derived from these antibodies fortherapeutic and diagnostic use in association withcardiovascular diseases. Additionally, the present invention relates tofragments of the monoclonal antibodies that recognizesulphatides and sulphated proteoglycans, such that said fragments may be usedin the treatment or diagnosis of this pathologicalcondition.
