A bone staple extrusion instruments used for fixation of bone and soft tissue of the musculoskeletal system and the methods for their use and manufacture. The bone staple extrusion instruments are used for insertion of staples into bones, which staples change shape through their metallurgic properties and the release from the bone staple extrusion instruments. In some embodiments, the bone staples pull together and compress bone once released from the bone staple extrusion instruments. In other embodiments, the staples push outward to place the bones in tension once released from the bone staple extrusion instrument.