The present invention relates to a compound of formula (I) as insulinsecretion stimulators, wherein the compound of formula (I) has the structure:(see formula I)wherein n = 2； R1 is alkyl, alkenyl or alkynyl optionally substituted by oneor more Y； R2is hydrogen； R3 is hydrogen, halogen or aryl optionally substituted by one ormore Y； R4is: arylalkyl or aryloxyalkyl optionally substituted by one or more Y； or R4is(see above formula)wherein: m = 1-6； R7 and R8 together constitute a heterocycle including one ormoreheteroatoms from N, O and S； Y is hydroxy, thio, halogen, cyano,trifluoromethoxy,trifluoromethyl, carboxy, carboxy methyl, carboxyethyl, alkyl, alkoxy,alkylamino, aryl, arylsulfonylalkyl, aryloxy, arylalkoxy, amino, NR5R6, azido, nitro, guanidino,amidino,phosphono, oxo, carbamoyl, alkylsulfonyl, alkylsulfinyl or alkylthio, or two Ygroups forma methylenedioxy； wherein R5 and R6 are independently hydrogen, alkyl, aryl,arylalkyl,heteroaryl, heteroarylalkyl； wherein alkyl, aryl and heteroaryl groups areoptionallysubstituted by one or more Y； or R5 and R6 together constitute a heterocycleincludingone or more heteroatoms from N, O and S； or a racemic form, tautomer,enantiomer,diastereomer, epimer or polymorph, or a mixture thereof, or a pharmaceuticallyacceptable salt thereof.
