Described is a system for affecting intestinal microbial flora. The system includes an intestinal sleeve that is implanted in a patient and bypasses a section of the intestine and probiotics, prebiotics or pharmacologic therapy used in combination with the intestinal sleeve. Also described are related methods. This invention relates to implants that are placed within gastrointestinal organs including in the distal portion of the stomach and the small intestine. In particular, it relates to an implant system and method that can be placed by endoscopic means, in order to reduce colonization of the intestines by certain bacteria and treat chronic diseases.
