THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
WOODS JAMES H.,LANDRY DONALD,MACDONALD JOANNE,STOJANOVIC MILAN N.,SUNAHARA ROGER K.,NARASIMHAN DIWAHAR,TESMER JOHN J. G.,BRIM REMY L.
申请号：
NZ62185908
公开号：
NZ621859A
申请日:
2008.07.10
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a method for identifying a thermostabilization compound, the method comprising: measuring thermostability of a cocaine esterase (CocE) at a first high temperature selected from the group consisting of 34°C, about 37°C, 40°C, 42.5°C, 45°C, greater than about 50°C, and greater than about 95°C combining the CocE and a candidate compound, the candidate compound present at a concentration of less than about 1mM measuring thermostability of the CocE in combination with the candidate compound at the high temperature determining whether the candidate compound increases thermostability of the CocE.
