Methods and treatments are taught for the diagnosis and treatment of breast conditions, including proliferative breast disease, ductal hyperplasia, lobular hyperplasia, atypical ductal hyperplasia, atypical lobular hyperplasia, ductal carcinoma in situ, lobular carcinoma in situ, lobular carcinoma and invasive breast cancer. The methods and compositions deliver efficacious formulations of chemical and/or biological treatment medicaments to the breast via a transpapillary route.