Patrick Y. Lu,Vera Simonenko,David Evans,John J. Xu
申请号：
US13695073
公开号：
US09642873B2
申请日:
2011.05.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides compositions and methods for using combinations of TGFβ1 and Cox-2 inhibitors and TGFβ1 and Hoxb13 inhibitors for the treatment of various medical conditions, including skin scaring due to trauma wounds and surgery, corneal and retina scaring due to injury and surgery, internal organ scaring due to injury and surgery, heart tissue scaring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. One example is to use siRNA inhibitors to silence TGFβ1 and Cox-2 at the same time, resulting in significant less scar formation.
