The present invention pertains generally to the field of therapeutic compounds, and more specifically to 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds of the following formula, wherein -A and &mdashB are as defined herein (collectively referred to herein as 38TM compounds): The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.本発明は、一般に、治療化合物の分野、より具体的には、次式の3-置換-8-置換-3H-イミダゾ[5,1-d][1,2,3,5]テトラジン-4-オン化合物に関し、式中、-A及び-Bは本明細書で定義の通りである(本明細書では総称して38TM化合物と呼ぶ):(1)。本発明はまた、かかる化合物を含む医薬組成物、並びに細胞増殖を阻害するための、がんなどの増殖性障害の治療における、かかる化合物及び組成物のインビトロ及びインビボ両方における使用、並びにかかる化合物の調製方法に関する。【化1】
