Disclosed are nitrile derivatives and pharmaceutical compositions comprisingnitrile derivatives. The pharmaceuticalcompositions comprise compounds of the formula I:(I) and the pharmaceuticallyacceptable salts of such compounds. Alsodisclosed are processes for the preparation of such compounds, intermediatesused in the preparation of such compounds, and theuses of such compounds in treating hyperproliferative diseases, inflammatorydiseases and viral and bacterial infections andinducing apoptosis in cancer cells.