GUNIC ESMIR,CHEN CHIXU,VERNIER JEAN MICHEL,OUK SAMEDY
申请号：
ARP110102068
公开号：
AR081930A1
申请日:
2011.06.14
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
Here are the useful compounds in the regulation of sulfuric acid content in the blood, the formulas containing these compounds and the use methods. These compounds are used to treat or prevent diseases associated with abnormal levels of uric acid, including hirsute anemia, poliomyelitis, gout, hypertension, corona disease, stones, and kidney failure. Among other things, 1: a compound (1),Among them: RA and Rb are selected from h, halogen and C1-6 tar； or RA and Rb, together with the carbon atoms attached to them, form a 3 -.4...5 - or 6-member, optionally containing one or two heteroatoms selected from O, N and S； m is h, c1-3 tar or pharmaceutically acceptable absorption； X1 is n, CH, C (halogen) or C (C1-4 tar)；X2 is n or CH； X3 is n, CH, C (halogen) or C (C1-4 tar)；X4 is n or CH； at least one of x1, X2, X3 or X4 is n； Y1 is n or CR1； Y2 is n or CR2； R1 is h, CF3, CH3, OCH3, f or Cl； R2 is h, methyl, ethyl, propyl, isopropyl, tributyl, cyclopentadiene, cyclopentadiene, CF3, O H, OCH3, etoxi, SH, SC3, sc2ch3, ch2ll, C (CH3), COO, RS2Wherein R2 and RS2 are h or c1-3 tar； R3 is h, halogen, CN, C1-6 tar, Alcoy C1-6； R4 is h, halogen, CN, C1-6 tar, C1-6 tar, alcox C1-6； or R3 and R4, together with the carbon atoms to which they are attached, form an optional 5 or 6 alternative ring, a. It can optionally contain one or two heteromorphic atoms selected from O, N and s, of which the rings of 5 or 6 members can be saturated, unsaturated or aromatic； if x2 and X4 are both N, X1 cannot be C (halogen)；Or, if both x2 and X4 are n, R4 cannot be CL； or if both x2 and X4 are n, Y2 cannot be C-Cl； if both X1 and X2 are n, X3 cannot be C-Cl； moreover, since the compound of formula (1) is not 1 - (3 - (4-cianophonil) piridin-4-iltio) cyclopropanic acid.Se describen aquí compuestos útiles en la modulación de los niveles de ácido úrico en la sangre, formulaciones que los contienen y métodos para utilizarlos. Los compuestos descritos aquí se utilizan en el tratamiento o prevención de t
