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COMBINAISONS D'INHIBITEURS DE BTK ET RÉGIME DE DOSAGE
专利权人:
Pharmacyclics LLC
发明人:
JAGLOWSKI, Samantha M.
申请号:
EP15874346
公开号:
EP3236968A4
申请日:
2015.12.22
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Disclosed herein are methods and combination dosing regimen of administering a combination of a BTK inhibitor (e.g. ibrutinib) and an anti-CD20 therapeutic agent for the treatment of a hematologic malignancy. In one aspect is a combination dosing regimen for the treatment of a hematologic malignancy in a subject in need thereof comprising a first phase and a second phase, wherein the first phase is an administration of a BTK inhibitor as a single-agent treatment for a first extended period of time, and the second phase is an administration of a combination of the BTK inhibitor and an anti-CD20 therapeutic agent for a second extended period of time. In one embodiment, the first extended period of time is a period of up to 90 days.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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