THE JACKSON LABORATORY;INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
HOWELL, Gareth,SASNER, Michael,CARTER, Gregory,LAMB, Bruce
申请号：
WO2018US23565
公开号：
WO2018175581(A8)
申请日:
2018.03.21
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non- familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.
