[Problem] To provide a transgenic (TG) non-human mammal expressing human matrix metalloproteinase 2 (hMMP2) in all body tissues, and a model animal for COPD onset. [Solution] The problem is solved by means of an hMMP2-expressing TG non-human mammal characterized by including a promoter for gene expression, and an entire hMMP2 gene region which is disposed downstream of the promoter and in which expression is systemically induced. The promoter for gene expression is preferably a β-actin promoter, and the non-human mammal is preferably a mouse. Chronic obstructive pulmonary disease (COPD) can be induced by making the TG non-human mammal inhale a tobacco smoke extract.
