Pyrimidine urea derivatives as kinase inhibitor农业专利-农业专业知识服务系统

发明人:: 丁强,N．S．格雷,李冰,刘异,劉異,沈台辅,沈台輔,宇野哲郎,张国宝,張國寶,C．皮索特索德曼,W．布赖滕施泰因,W．布賴滕施泰因,G．博尔德,G．博爾德,G．卡拉瓦蒂,P．菲雷,V．瓜格纳诺,V．瓜格納諾,M．兰,M．蘭,P．W．曼雷,J．舍普费尔,J．舍普費爾,C．斯庞克,C．斯龐克,N.S.格雷,C.皮索特索德曼,W.布赖滕施泰因,W.布賴滕施泰因,G.博尔德,G.博爾德,G.卡拉瓦蒂,P.菲雷,V.瓜格纳诺,V.瓜格納諾,M.兰,M.蘭,P.W.曼雷,J.舍普费尔,J.舍普費爾,C.斯庞克,C.斯龐克

摘要：: The present invention relates to formula (I) compounds, wherein substituent X 1, R1, R2, R3 and R4 have the meaning as proposed and explaining in the description of the present invention, prepare these compounds method, containing its pharmaceutical composition, it optionally combines in treatment with one or more other pharmaceutically active compounds to the purposes in the disease for inhibiting protein kinase activity response, and the method for the treatment disease.本發明涉及式(I)化合物，其中取代基X1、R1、R2、R3和R4具有如在本發明的描述中所提出和解釋的含義，製備這些化合物的方法、含有其的藥物組合物、其任選與一種或多種其它藥學活性化合物組合在治療對抑制蛋白激酶活性響應的疾病中的用途，以及治療所述疾病的方法。