The present invention generally relates to systems and methods for delivering and/or withdrawing fluid from subjects, e.g., through the skin, including packaging associated with such systems. Certain aspects of the invention are generally directed to devices for withdrawing a substance from the skin and/or from beneath the skin of a subject, and/or for delivering a substance to the skin and/or to a location beneath the skin of a subject. In some embodiments, the devices may comprise one or more skin insertion objects, such as needles or microneedles. In some cases, the device also may comprise one or more vacuum chambers, e.g., having an internal pressure less than atmospheric pressure. In some aspects, the device may be contained within an environment able to assist with maintenance of such pressures. For example, a package containing such an environment may also have a pressure less than atmospheric pressure, and/or the package may be molded to the device or otherwise have a shape that does not contain substantial gases that can &ldquoleak&rdquo into the device and alter the pressure of any vacuum chambers that may be contained therein. In some embodiments, the pressure of the environment may be the same as or less than that of vacuum chambers contained within the device. Other aspects of the invention are generally directed to methods of creating such devices, techniques for using such devices, kits involving such devices, and the like.本出願は一般に、被験体の皮膚および/もしくは皮膚の下から物質を抜き取り、かつ/または被験体の皮膚および/もしくは皮膚の下の位置へ物質を送達するデバイスに関する。デバイスは、針または顕微針などの1つまたは複数の皮膚挿入物と、大気圧より低い内圧を有する1つまたは複数の真空チャンバとを備える。デバイスは、そのような圧力の維持を助けることができる環境内に収容される。例えば、そのような環境を収容するパッケージはまた、大気圧より低い圧力を有することができ、かつ/またはパッケージは、デバイスに合わせて成型することができ、もしくはその他の方法で、デバイス内へ「漏れ」て真空チャンバの圧力を変えうるのに十分な気体を収容しない形状を有することができる。
