Provided is a medicinal agent useful for the prevention and/or treatment of hepatocellular carcinoma. A medicinal agent for preventing and/or treating hepatocellular carcinoma, which comprises a combination of a non-cyclic retinoid, a salt of the retinoid or a solvate of the retinoid or the salt and a branched amino acid, a salt of the amino acid or a solvate of the amino acid or the salt.本發明提供一種對肝細胞癌之預防及/或治療有用之醫藥。本發明之醫藥係組合非環式類視色素或其鹽或該等之溶劑合物、及支鏈胺基酸或其鹽或該等之溶劑合物而成的肝細胞癌之預防及/或治療用醫藥。
