RHEIN BIOTECH GESELLSCHAFT FUER NEUE BIOTECHNOLOGISCHE PROZESSE UND PRODUKTE MBH
发明人:
MELBER, KARL,BUCHMANN, PASCALE,JANOWICZ, ZBIGNIEW
申请号：
AT06792095
公开号：
AT556089T
申请日:
2006.09.15
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
Composition (A) comprises (i) one or more hepatitis B core antigens (HBcAg) containing amino acids 1 to x (x = 100-160),their fragments, variants of fragment variants； (ii) an adjuvant containing a saponin and/or saponin derivative； and (iii) optionally, one or more hepatitis B surface antigens (HBsAg), or their fragments, variants or variant fragments. ACTIVITY : Virucide； Hepatotropic； Antiinflammatory. Mice were immunized with a composition containing 5 mu g AbISCO-200 (RTM for a saponin composition) and 10 mu g HBcAg1-144+1 in 0.1 ml phosphate-buffered saline. The number of CD8 +>； cells that expressed gamma -interferon was just over 100 per 10 5>； such cells； compared with zero when the same antigen was administered without saponin. When the composition also contained 5 mu g HBsAg, the number of such cells was 170/10 5>；. The composition also resulted in high levels of immunoglobulins G1 and G2b, indicating a Th1/Th2 response. MECHANISM OF ACTION : Vaccine.
