Robert Niichel,Samuel Reinhold, III,Clayton J. Nelsen,Dan A. Finkbeiner,Roy J. McDaniel,Andrew D. Padilla
申请号：
US16269130
公开号：
US20190240163A1
申请日:
2019.02.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Various embodiments of modified-release multiparticulates (in bead or granule from) are described. The modified-release multiparticulates can comprise a core including a pharmaceutical and/or probiotic agent, optionally with additional excipients or binders to aid in creation of the core, one or more functional coatings disposed on the core and configured to provide a modified-release profile of the pharmaceutical and/or probiotic agent when given orally, and a coating of hypromellose acetate succinate (HPMCAS) disposed on the one or more functional coatings and configured to impart multiparticulate stability in aqueous acidic media. Suspensions including the modified-release multiparticulates are also described.
