Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.所描述者係含有半衰期延長蛋白、連接子、及GDF15蛋白的融合蛋白。亦描述者係編碼融合蛋白之核酸、其重組細胞、包含融合蛋白之組成物、以及使用融合蛋白以治療或預防代謝疾病、病症或病況之方法。