Claude Perreault,Diana Paola Granados,Jean-Sébastien Delisle,Pierre Thibault,Sébastien Lemieux
申请号：
US15548749
公开号：
US20180030112A1
申请日:
2016.02.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Novel minor histocompatibility antigens (MiHAs) are described. These novel MiHAs were selected based on two features: (i) they are encoded by loci with a minor allele frequency (MAF) of at least 0.05； and (ii) they have adequate tissue distribution. Compositions, nucleic acids and cells related to these novel MiHAs are also described. The present application also discloses the use of these novel MiHAs, and related compositions, nucleic acids and cells, in applications related to cancer immunotherapy, for example for the treatment of hematologic cancers such as leukemia.
