The nucleotomy device makes it possible to produce a nuclear space Es in an intervertebral disc Di using a transosseous approach previously pierced in the body of a vertebra Va. The device includes a tool holder (2) provided with first connection elements (3) ensuring the placement of an electric rotary driving motor (4), second connection elements (5) for the placement of a blade cutting tool (6), driving elements (7) imparting rotational and longitudinal translational movements to the cutting tool (6), and injection and suction elements (8) making it possible to evacuate the debris from the nucleus resulting from cutting when it is formed inside the intervertebral disc.