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Antifolate compounds for the treatment of melanoma
专利权人:
Jose Neptuno Rodriguez-Lopez
发明人:
Jose Neptuno Rodriguez-Lopez,Luis Sanchez Del Campo Ferrer,Juan Cabezas-Herrera,Alberto Tarraga Tomas,Magali Maria Saez Ayala
申请号:
US12809713
公开号:
US09060997B2
申请日:
2008.12.18
申请国别(地区):
US
年份:
2015
代理人:
摘要:
This invention relates to compounds of the formula X) or Xl) (X) (XI) wherein: each —R1, —R2 and —R3 is independently -Q1, —OH or —H, where at least one of —R1, —R2 and —R3 is not —H or —OH each —R4 and —R5 is independently -Q2 or —H each -Q1 is independently selected from: —F, —Cl, —RA, —ORA, —SH, —SRA, where each —RA is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups and each -Q2 is selected from: —F, —Cl, —RB, —ORB, —SH, —SRB, where each —RB is independently selected from methyl and ethyl, which may substituted by one or more fluoro or chloro groups which are useful in the treatment of melanoma.
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