Tae-Wan Kim,Gilbert Di Paolo,Min Suk Kang,Diego Berman,Laura Beth Johnson McIntire
申请号：
US12467583
公开号：
US08288378B2
申请日:
2009.05.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or “PIP”) and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or “PIP2”), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with γ-secretase and lipid rafts.
