ORWAT MICHAEL J.,PINTO DONALD J.P.,SMITH II LEON M.,SRIVASTAVA SHEFALI
申请号：
NZ62487412
公开号：
NZ624874A
申请日:
2012.10.12
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. The disclosed compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments for the treatment or prophylaxis of thromboembolic inflammatory disorders. An example of a compound of formula (I) is: (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(piperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid
