Uwe Zangemeister-Wittke;Claudio Di Paolo;Dominique Christine Tschudi;Nicholas Ronald Glover;Dimitri Peter Fitsialos
发明人:
Uwe Zangemeister-Wittke,Claudio Di Paolo,Dominique Christine Tschudi,Nicholas Ronald Glover,Dimitri Peter Fitsialos
申请号：
US12698434
公开号：
US08545840B2
申请日:
2010.02.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to methods for preventing or treating head and neck squamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the cancer cell attached to； (b) a toxin that is cytotoxic to the cancer cell. In a specific embodiment, the invention is directed to the prevention or treatment of head and neck squamous cell cancer or bladder cancer using VB4-845, which is a recombinant immunotoxin comprising a humanized, MOC31-derived, single-chain antibody fragment that is fused to a truncated form of Pseudomonas exotoxin A. Also encompassed by the invention are combination therapy methods, including the use of reduced dosages of chemotherapeutic agents, for the prevention or treatment of cancer. Also encompassed by the invention are formulations and methods for direct administration of the recombinant immunotoxin to the carcinoma, for the prevention or treatment of cancer.
