A Medicine composition for treating leukemia, mainly prepared from, by weight, 2-8% of realgar, 25-42% of indigo naturalis, 50-60% of salviae miltiorrhizae and 6-10% of radix pseudostellariae. The invention improves the preparation method for salviae miltiorrhizae, reduces the amount of added water, the times of decoction and the decoction time. The extraction rate of tanshinone IIA reaches 75%. The medicine composition provided by the invention can be used for treating leukemia, having a complete remission rate of 92.9%, improved curative effect, and reduced toxic and side effect.