THE UNIVERSITY OF BRITISH COLUMBIA;HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF AGRICULTURE AND AGRI-FOOD;THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
发明人:
BRUMER, Harry,HUI, Benjamin,WANG, Chang Qing,INGLIS, Gordon Douglas,CLARKE, Sandra Theresa,UWIERA, Richard Robert Ernest,ABBOTT, Dennis Wade
申请号：
CACA2020/050447
公开号：
WO2020/198878A1
申请日:
2020.04.03
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The present application provides compounds, compositions and methods to reduce, alleviate or treat various enteric diseases and disorders, such as inflammatory bowel disease. The compounds are xyloglucan-containing prodrugs, referred to herein as glyco-caged prodrugs, of formula (I) or (II), xyloglucan-β-O-RD (I), xyloglucan-β-O-LSI-RD (II).La présente invention concerne des composés, compositions et méthodes pour limiter, soulager ou traiter diverses maladies et affections entériques, telles que les maladies intestinales inflammatoires. Les composés sont des promédicaments contenant du xyloglucane, désignés dans la description comme promédicaments glyco-bloqués, de formule (I) ou (II), xyloglucane-β-O-RD (I), xyloglucane-β-O-LSI-RD (II).
