Histone deacetylase inhibitors for enhancing activity of antifungal agents

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专利权人:

METHYLGENE INC.

发明人:

GEORGOPAPADAKOU, NAFSIKA,HU, WENQI,CAMPEOL, NADIA,BEDARD, JEAN,DEZIEL, ROBERT,AJAMIAN, ALAIN

申请号：

AU2012201671

公开号：

AU2012201671A1

申请日:

2012.03.21

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The present invention relates to compounds, compositions thereof and methods to selectively treat fungal infections. More particularly, this invention relates to compounds, compositions thereof and methods for selectively enhancing fungal 5 sensitivity to antifungal compounds. The compounds are hydroxamate-based inhibitors of histone deacetylase (HDAC) which show synergistic activity with antifungal agents against fungal species at concentrations of inhibitor non toxic to mammalian cells.

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