Ching-Shih Chen,Samuel K. Kulp,Dasheng Wang,John C. Byrd,Natarajan Muthusamy
申请号：
US13305927
公开号：
US20120136063A1
申请日:
2011.11.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A number of FTY720-derived compounds with antitumor activity are described. These compounds include the compounds of formula I:wherein R1 is independently selected from the group consisting of hydrogen, methyl. methoxy, and hydroxyl R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl R3 is independently selected from the group consisting of alkyl and cyclo-alkyl and n is independently selected from 0 to 6. The compounds have lower immunosuppressive side effects as a result of not being phosphorylated by sphingosine kinase 2.
