BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
发明人:
DHURANDHAR NIKHIL
申请号：
NZ60623611
公开号：
NZ606236A
申请日:
2011.07.08
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is the use of Adenovirus-36 E4orf1 protein, wherein said protein is SEQ ID NO:2 or SEQ ID NO:4, or a functional variant thereof, wherein said functional variant has at least 85% sequence identity to SEQ ID NO:2 or SEQ ID NO:4, or a nucleic acid encoding Adenovirus-36 E4orf1, wherein said nucleic acid is SEQ ID NO:1 or SEQ ID NO:3 or a functional variant thereof, wherein said functional variant has at least 85% sequence identity to SEQ ID NO:1 or SEQ ID NO:3, in the manufacture of a medicament for the treatment or prevention of non-alcoholic fatty liver disease in an individual. Further disclosed is the use of medicament as disclosed above for reducing excessive fat from the liver of an individual； for the treatment or prevention of liver dysfunction in a patient characterized by fatty liver and insulin resistance； or for reducing or preventing non-alcoholic steatohepatitis (NASH) in a patient.
