There are disclosed a method to enhance sternal treatment after sternotomywith or without removal of at least onE of thoracic arteries which comprisesapplying an agent for the treatment of sternum after sternotomy to or ataround the sternum, wherein the agent comprises at least one selected from thegroup consisting of an angiogenetic factor, an osteogenetic factor and theiranalogues such as bFGF, aFGF, TGF .beta., VEGF, HGF, BMP, PDGF, TGF .alpha.,other cytokines or gene as an effective ingredient and an agent to be used forthe method； an agent to enhance healing of or treating sternum aftersternotomy comprising the same and use of the agent.
