FACTOR XII (HAGEMAN FACTOR) (F12) KALLIKREIN B PLASMA (FLETCHER FACTOR) 1 (KLKB1) AND KININOGEN 1 (KNG1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF

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专利权人:

发明人:

AKINC AKIN,HINKLE GREGORY,MAIER MARTIN,BUTLER JAMES,LIU JINGXUAN

申请号：

IN201747043455

公开号：

IN201747043455A

申请日:

2017.12.04

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

The present invention relates to RNAi agents e.g. double stranded RNAi agents targeting the Kallikrein B Plasma (Fletcher Factor) 1 (KLKB1) gene the Factor XII (Hageman Factor (F12) gene or the Kininogen 1 (KNG1) gene and methods of using such RNAi agents to inhibit expression of a KLKB1 gene an F12 gene and/or a KNG1 gene and methods of treating subjects having an hereditary angioedema (HAE) and/or a contact activation pathway associated disorder.

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