CHANG, WEI HONG,张惟闳,張惟閎,YANG, MING CHIA,杨明嘉,楊明嘉,LIN, YUN HAN,林芸含,林芸含,KUO, KUN MAO,郭崑茂,郭崑茂,WANG, YUCHI,王羽淇,王羽淇,SHEN, HSIN HSIN,沈欣欣,沈欣欣,LIN, LI JIE,林立杰,林立傑
申请号：
TW108109790
公开号：
TW201927899A
申请日:
2017.12.21
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
The present disclosure provides a film composed of a polymer mixture, wherein the polymer mixture including: a hydrophobic composition including polycaprolactone (PCL)； and at least one hydrophilic polymer selected from a group consisting of: alginate, gelatin, hyaluronic acid, polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), polyethylene glycol (PEG), collagen, demineralized bone matrix (DBM), bone morphogenetic protein (BMP), albumin, chitosan, fibrin, polyoxyethylene and polyvinylpyrrolidone, wherein a weight ratio of the hydrophobic composition to the at least one hydrophilic polymer is about 1:0.01-100, and wherein the film has an effect of preventing leakage from a surgical wound or dysfunctional wound.本發明提供一種薄膜，係由一高分子混合物所構成，其中該高分子混合物包括：一疏水性成分，其包括聚己內酯(polycaprolactone,PCL)；以及至少一親水性高分子，其係擇自由下列所組成之群組：褐藻膠(alginate)、明膠(gelatin)、玻尿酸(hyaluronic acid)、聚乙烯醇(polyvinyl alcohol,PVA)、甲基纖維素(carboxymethyl cellulose,CMC)、聚乙二醇(polyethylene glycol,PEG)、膠原蛋白(collagen)、去礦化骨基質(demineralized bone matrix,DBM)、骨塑型蛋白(bone morphogenetic protein,BMP)、白蛋白(albumin)、幾丁聚醣(chitosan)、纖維蛋白(fibrin)、聚氧化乙烯(polyoxyethylene)與聚乙烯吡咯烷酮(polyvinylpyrrolidone)，其中該疏水性成分與該至少一親水性高分子的重量比為約1：0.01-100，又其中該薄膜對於手術傷口或瀰漫性傷口具有防止滲漏的效果。
