Improved microparticles comprising a somatostatin Analogue, to a process for the preparation of these microparticles, and to pharmaceutical compositions that comprise. Kit. Use. Method of treatment.Claim 1: for an extended release Pharmaceutical composition, which comprises microparticles with a Polymer Matrix comprising one or more biodegradable Polymers and pirantel Compound as active ingredientWhere the maximum plasma concentration of the active ingredient in rabbits within the first 24 hours after the Administration of 4 mg / kg, is below 15 nanograms / milliliter.Claim 2: the pharmaceutical composition according to any one of claims 1 to 5, where the polymer Matrix comprising a Poly l u00e1ctido co glycolide linear and branched.Ovaj pronalazak odnosi se na poboljšane mikročestice koje sadrže analog somatostatina, na postupak pripreme navedenih mikročestica kao i na farmaceutske kompozicije koje sadrže isti sastojak.
