Disclosed herein are desazadesferrothiocin and desazadesferrothiocin polyether analogue compounds, of general formula III, wherein the substituents are as defined within the specification. Said compounds are useful as metal chelation agents and can be used in the treatment of beta-thalassemia major and intermedia, sickle cell anemia, Diamond-Blackfan anemia, sideroblastic anemia, chronic hemolytic anemias, off-therapy leukemias, bone marrow transplant and myelodysplastic syndrome.
