TAHRI, Abdellah,JONCKERS, Tim Hugo Maria,RABOISSON, Pierre Jean-Marie Bernard,DEMIN, Samuël Dominique
申请号：
ES14701389
公开号：
ES2616784T3
申请日:
2014.01.27
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound that satisfies the formula I ** Formula ** or a stereochemically isomeric or tautomeric form thereof in which: X independently is CH or N； Y is N or N-R4； Z1 is N or C-R6； Z2 is N or C-R3； n is an integer from 1 to 6； R1 is selected from the group of H, halogen, C1-C6 alkyl and C3-C7 cycloalkyl； R2 is - (CR7R8) n-R9； R3 is selected from the group consisting of H, C1-C6 alkyl, C3-C7 cycloalkyl, CF3 and halogen； R4 is selected from the group consisting of H, C1-C6 alkyl and C3-C7 cycloalkyl； R6 is selected from the group consisting of H, halogen, aryl and heteroaryl, in which aryl or heteroaryl are optionally substituted with one or more R10； R7 and R8 are each independently selected from H, C1-C6 alkyl or C3-C7 cycloalkyl； R9 is selected from the group consisting of H, halogen, SO2R7, C1-C6 alkyl, CONR7R8, COOR7, OH, CN, F, CFH2, CF2H and CF3； R10 is selected from the group consisting of H, OH, CN, halogen, CFH2, CF2H, CF3, CONR7R8, COOR7 and C1-C6 alkyl optionally substituted with one or more substituents selected from the group comprising NR7R8, CF3, CH3, OCH3, OCF3 , morpholinyl or halogen； or an addition salt or solvate thereof.Un compuesto que satisface la fórmula I**Fórmula** o una forma estereoquímicamente isomérica o tautomérica de los mismos en la que: X independientemente es CH o N； Y es N o N-R4； Z1 es N o C-R6； Z2 es N o C-R3； n es un número entero de 1 a 6； R1 se selecciona del grupo of H, halógeno, alquiloC1-C6 y cicloalquiloC3-C7； R2 es -(CR7R8)n-R9； R3 se selecciona del grupo que consiste en H, alquiloC1-C6, cicloalquiloC3-C7, CF3 y halógeno； R4 se selecciona del grupo que consiste en H, alquiloC1-C6 y cicloalquiloC3-C7； R6 se selecciona del grupo que consiste en H, halógeno, arilo y heteroarilo, en el que arilo o heteroarilo están opcionalmente sustituidos con uno o más R10； R7 y R8 se eligen cada uno independientemente de H, alquiloC1-C6 o cicloalquiloC3-C7； R9 se selecciona del grupo que consiste en H, halógeno, SO2R7, alquiloC1-C6, CONR
