THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
MONSON, NANCY
申请号：
CA2852469
公开号：
CA2852469A1
申请日:
2012.10.18
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides for the diagnosis and prediction of neuromyelitis optica (NMO) in subject utilizing a unique a codon signature in B cells that has now been associated with NMO and not with any other autoimmune disease. More particularly, the method may comprise the steps of (a) providing a 10 B-cell containing sample from a subject, or DNA or RNA isolated therefrom； (b) determining the the VH1 and/or VH4 structure of VH1NH4-expressing B-cells from said subject, (c) determining the mutational frequency VH1 and/or VH4 genes； (d) identifying the presence or absence of a codon signature associated with NMO or risk of NMO； and (e) selecting patients exhibiting said codon signature.
