Disclosed is an anti-hypertensive agent. The anti-hypertensive agent comprises at least one peptide selected from the group consisting of peptides respectively comprising the amino acid sequences (1) to (6) which are derived from a globin protein digest or a globin protein digest containing at least one of the above-mentioned peptides as an active ingredient: (1) Val-Val-Tyr-Pro (SEQ ID NO:1) (2) Trp-Gly-Lys-Val-Asn (SEQ ID NO:2) (3) Trp-Gly-Lys-Val (SEQ ID NO:3) (4) Trp-Gly-Lys (SEQ ID NO:4) (5) Ala-Ala-Trp-Gly-Lys (SEQ ID NO:5) and (6) Phe-Glu-Ser (SEQ ID NO:6).