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FORMULAÇÕES DE ANTICORPO
专利权人:
NOVARTIS AG
发明人:
申请号:
ARP170102392
公开号:
AR109461A2
申请日:
2017.08.29
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
This invention relates to a shear and temperature stable antibody formulations that are more stable than compared to a standard formulation (such as 30 mM citrate, 10OmM NaCl, pH 6.5). The present inventions shear and temperature stable antibody formulations show reduced precipitation when subjected to stress conditions but the standard formulation had aggregated. This result was unpredictable because thermodynamically the two formulations are similar as seen by their DSC (differential scanning calorimeter) profiles.
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