Board of Regents of the University of Texas System
发明人:
Van Rooij, Eva,Olson, Eric
申请号：
AU2007281261
公开号：
AU2007281261B2
申请日:
2007.07.31
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders.
