Huw M. Nash,Rosana Kapeller-Libermann,Jia-wen Han,Tomi K. Sawyer,Justin Noehre,Noriyuki Kawahata
申请号：
US13497522
公开号：
US20130072439A1
申请日:
2010.09.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
